Imprex® SLF Characteristics

Instantaneous Freezing

• Proteins pass from liquid to "glass" state
• Proteins never have chance to re-organize / degrade into crystals
• Proteins do not have chance to diffuse to ice-water interface

No Exposure to Air/Water Interface

Unlike competitive processes (e.g. spray drying, spray freeze drying, lyophilization), proteins are never exposed to heat or to the air and therefore never have the chance to aggregate/degrade

Produces Stable Dry Powders

• Pulmonary and Nasal Inhalers
• Fast-releasing oral tablets

Layer "Imprexed" proteins into microspheres

• High loading efficiencies
• Depot Release (controlled sustained release without unwanted bursts)
• Injectable Liquids (fast release)
• Pulmonary Liquids (fast or sustained release)
• Oral capsules/tablets (fast or sustained release)

Produces High Surface Area Particles

Exponential increase in surface area and therefore bioavailability (between 10 and 100 nm to 5 micrometers in size) without loss of stability.

Produces Particles with Uniform Size & Shape Distributions

Enhanced loading efficiencies in microspheres with no long term bursts